T1ρ relaxation time in brain regions increases with ageing: an experimental MRI observation in rats.

Autor:	Zhao F; 1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong., Yuan J; 1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.; 2 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong., Lu G; 3 Division of Neurosurgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong., Zhang LH; 4 School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong., Chen ZY; 5 Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wáng YX; 1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Jazyk:	angličtina
Zdroj:	The British journal of radiology [Br J Radiol] 2016; Vol. 89 (1057), pp. 20140704. Date of Electronic Publication: 2015 Nov 03.
DOI:	10.1259/bjr.20140704
Abstrakt:	Objective: T1ρ variation is associated with neurodegenerative diseases. This study aims to observe T1ρ relaxation time changes in rat brains associated with normal ageing in Sprague-Dawley (SD) rats, Wistar Kyoto (WKY) rats and spontaneously hypertension rats (SHRs). Methods: 18 male SD rats, 11 male WKY rats and 11 male SHRs were used. T1ρ measurement was performed at 3-T MR with a spin-lock frequency of 500 Hz. SD rats were scanned at the ages of 5, 8, 10 and 15 months. SHRs and WKY rats were scanned at the ages of 6, 9 and 12 months. Results: For SD rats, T1ρ at the thalamus, hippocampus and frontal cortices increased significantly from 5 to 15 months (p < 0.05). For the WKY rats and SHRs, the T1ρ values in the thalamus, hippocampus and frontal cortices also increased significantly from 6 to 12 months (p < 0.05). Furthermore, T1ρ in the thalamus, hippocampus and frontal cortices of SHRs were consistently higher than those of WKY rats at the ages of 6, 9 and 12 months (p < 0.05). The percentage regional T1ρ differences between WKY rats and SHRs did not change during ageing. Conclusion: An increase in T1ρ was associated with age-related changes of the rat brain. Advances in Knowledge: An age-related and hypertension-related T1ρ increase in rat brain regions was observed in the thalamus, hippocampus and frontal cortical regions of the rat brain.
Databáze:	MEDLINE
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