Clinical and pathogenetic features of early- and late-onset pre-eclampsia.

Autor:	Khodzhaeva ZS; a Department of Maternal-Fetal Medicine., Kogan YA; b Department of First Pathology , and., Shmakov RG; c Federal State Budget Institution 'Research Center for Obstetrics, Gynecology and Perinatology' of the Ministry of Healthcare of the Russian Federation , Moscow , Russia., Klimenchenko NI; a Department of Maternal-Fetal Medicine., Akatyeva AS; c Federal State Budget Institution 'Research Center for Obstetrics, Gynecology and Perinatology' of the Ministry of Healthcare of the Russian Federation , Moscow , Russia., Vavina OV; c Federal State Budget Institution 'Research Center for Obstetrics, Gynecology and Perinatology' of the Ministry of Healthcare of the Russian Federation , Moscow , Russia., Kholin AM; a Department of Maternal-Fetal Medicine., Muminova KT; c Federal State Budget Institution 'Research Center for Obstetrics, Gynecology and Perinatology' of the Ministry of Healthcare of the Russian Federation , Moscow , Russia., Sukhikh GT; c Federal State Budget Institution 'Research Center for Obstetrics, Gynecology and Perinatology' of the Ministry of Healthcare of the Russian Federation , Moscow , Russia.
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2016 Sep; Vol. 29 (18), pp. 2980-6. Date of Electronic Publication: 2015 Dec 02.
DOI:	10.3109/14767058.2015.1111332
Abstrakt:	Background: PE is present in ∼2-8% of all pregnant women worldwide. Placental bed disorders at early and late PE have been not carried out yet. However, these studies help to explore details of the pathogenesis of PE, and to optimize the prognosis and obstetric management. Objective: To identify clinical and morphological differences between early- and late-onset PE based on a comprehensive observation of pregnant women with regard to morphological and immunohistochemical characteristics of the placental bed. Materials and Methods: One hundred fifty patients aged 18-43 years old delivered by cesarean section due to severe PE. The samples of placental bed tissue were studied by morphological and immunohistochemical methods. Results: The violation of invasion trophoblast, remodeling of spiral arteries were expressed in early onset PE; the degree of compensation of chronic hypoxia tissue in the area of the placental site was typical for late PE and was absent of an early onset PE. Conclusion: Our studies confirm the need for separation of early- and late-onset PE, being justified in terms of different pathogenetic mechanisms of formation, and therefore the possibility of therapeutic effects, duration of pregnancy prolongation, forecasting, search early diagnostic markers of the disease, and personalized approaches.
Databáze:	MEDLINE
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