The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice.

Autor:	Allais L; Department of Medical and Forensic Pathology, Ghent University, Ghent, Belgium., Kumar S; Laboratory for Translational Research in Obstructive Pulmonary diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Debusschere K; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University, Ghent, Belgium; VIB Inflammation Research Center, Ghent University, Ghent, Belgium., Verschuere S; Department of Pathology, AZ Sint-Jan, Brugge, Belgium., Maes T; Laboratory for Translational Research in Obstructive Pulmonary diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., De Smet R; Department of Medical and Forensic Pathology, Ghent University, Ghent, Belgium., Conickx G; Laboratory for Translational Research in Obstructive Pulmonary diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., De Vos M; Department of Gastroenterology, Ghent University, Ghent, Belgium., Laukens D; Department of Gastroenterology, Ghent University, Ghent, Belgium., Joos GF; Laboratory for Translational Research in Obstructive Pulmonary diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Brusselle GG; Laboratory for Translational Research in Obstructive Pulmonary diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Elewaut D; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University, Ghent, Belgium; VIB Inflammation Research Center, Ghent University, Ghent, Belgium., Cuvelier CA; Department of Medical and Forensic Pathology, Ghent University, Ghent, Belgium., Bracke KR; Laboratory for Translational Research in Obstructive Pulmonary diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Jazyk:	angličtina
Zdroj:	PloS one [PLoS One] 2015 Nov 02; Vol. 10 (11), pp. e0141570. Date of Electronic Publication: 2015 Nov 02 (Print Publication: 2015).
DOI:	10.1371/journal.pone.0141570
Abstrakt:	The inflammatory cytokine TNF-α is a central mediator in many immune-mediated diseases, such as Crohn's disease (CD), spondyloarthritis (SpA) and chronic obstructive pulmonary disease (COPD). Epidemiologic studies have shown that cigarette smoking (CS) is a prominent common risk factor in these TNF-dependent diseases. We exposed TNFΔARE mice; in which a systemic TNF-α overexpression leads to the development of inflammation; to 2 or 4 weeks of air or CS. We investigated the effect of deregulated TNF expression on CS-induced pulmonary inflammation and the effect of CS exposure on the initiation and progression of gut and joint inflammation. Upon 2 weeks of CS exposure, inflammation in lungs of TNFΔARE mice was significantly aggravated. However, upon 4 weeks of CS-exposure, this aggravation was no longer observed. TNFΔARE mice have no increases in CD4+ and CD8+ T cells and a diminished neutrophil response in the lungs after 4 weeks of CS exposure. In the gut and joints of TNFΔARE mice, 2 or 4 weeks of CS exposure did not modulate the development of inflammation. In conclusion, CS exposure does not modulate gut and joint inflammation in TNFΔARE mice. The lung responses towards CS in TNFΔARE mice however depend on the duration of CS exposure.
Databáze:	MEDLINE
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