A PROSTHETIC GROUP FOR THE RAPID INTRODUCTION OF FLUORINE INTO PEPTIDES AND FUNCTIONALIZED DRUGS.
| Autor: | Jacobson KA; Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 (U.S.A.)., Furlano DC; Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 (U.S.A.)., Kirk KL; Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 (U.S.A.). |
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| Jazyk: | angličtina |
| Zdroj: | Journal of fluorine chemistry [J Fluor Chem] 1988 Jun; Vol. 39 (3), pp. 339-47. Date of Electronic Publication: 2001 Mar 01. |
| DOI: | 10.1016/S0022-1139(00)81606-1 |
| Abstrakt: | Fluoride ion as the tetrabutylammonium salt displaces bromide in para-substituted benzyl bromides in acetonitrile or dimethylformamide. The p-bromomethyl benzoyl (BMB) group has been coupled to amino groups, including peptide amino groups, via its N-hydroxysuccinimide ester. In a subsequent step, the facile displacement of bromide by fluoride occurred under conditions compatible for use with (18)F radiotracers. |
| Databáze: | MEDLINE |
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