The effects of exercise on the lipoprotein subclass profile: A meta-analysis of 10 interventions.

Autor: Sarzynski MA; Pennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: sarz@mailbox.sc.edu., Burton J; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Rankinen T; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Blair SN; Department of Exercise Science, University of South Carolina, Columbia, SC, USA., Church TS; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Després JP; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada., Hagberg JM; Department of Kinesiology, University of Maryland, College Park, MD, USA., Landers-Ramos R; Department of Kinesiology, University of Maryland, College Park, MD, USA., Leon AS; School of Kinesiology, University of Minnesota, Minneapolis, MN, USA., Mikus CR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Seip RL; Cardiology Division, Hartford Hospital, Hartford, CT, USA., Skinner JS; Indiana University, Bloomington, IN, USA., Slentz CA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Thompson PD; Cardiology Division, Hartford Hospital, Hartford, CT, USA., Wilund KR; Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, IL, USA., Kraus WE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Jazyk: angličtina
Zdroj: Atherosclerosis [Atherosclerosis] 2015 Dec; Vol. 243 (2), pp. 364-72. Date of Electronic Publication: 2015 Oct 17.
DOI: 10.1016/j.atherosclerosis.2015.10.018
Abstrakt: Objective: The goal was to examine lipoprotein subclass responses to regular exercise as measured in 10 exercise interventions derived from six cohorts.
Methods: Nuclear magnetic resonance spectroscopy was used to quantify average particle size, total and subclass concentrations of very low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein particles (VLDL-P, LDL-P, and HDL-P, respectively) before and after an exercise intervention in 1555 adults from six studies, encompassing 10 distinct exercise programs: APOE (N = 106), DREW (N = 385), GERS (N = 79), HERITAGE (N = 715), STRRIDE I (N = 168) and II (N = 102). Random-effects meta-analyses were performed to evaluate the overall estimate of mean change across the unadjusted and adjusted mean change values from each exercise group.
Results: Meta-analysis of unadjusted data showed that regular exercise induced significant decreases in the concentration of large VLDL-P, small LDL-P, and medium HDL-P and mean VLDL-P size, with significant increases in the concentration of large LDL-P and large HDL-P and mean LDL-P size. These changes remained significant in meta-analysis with adjustment for age, sex, race, baseline body mass index, and baseline trait value.
Conclusions: Despite differences in exercise programs and study populations, regular exercise produced putatively beneficial changes in the lipoprotein subclass profile across 10 exercise interventions. Further research is needed to examine how exercise-induced changes in lipoprotein subclasses may be associated with (concomitant changes in) cardiovascular disease risk.
(Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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