Technical Note: Clinical translation of the Rapid-Steady-State-T1 MRI method for direct cerebral blood volume quantification.

Autor: Perles-Barbacaru TA; Clinatec INSERM UA01, Centre de Recherche Edmond J. Safra, CEA Grenoble, Grenoble 38054, France., Tropres I; IRMaGe, Université Grenoble Alpes, Grenoble 38054, France; US 017 INSERM, Grenoble 38054, France; and UMS 3552, CNRS, Grenoble 38054, France., Sarraf MG; Clinatec INSERM UA01, Centre de Recherche Edmond J. Safra, CEA Grenoble, Grenoble 38054, France., Chechin D; Philips Healthcare, Suresnes 92150, France., Zaccaria A; Clinatec INSERM UA01, Centre de Recherche Edmond J. Safra, CEA Grenoble, Grenoble 38054, France., Grand S; Department of Neuroradiology and MRI, Grenoble University Hospital, Grenoble 38054, France., Le Bas JF; Department of Neuroradiology and MRI, Grenoble University Hospital, Grenoble 38054, France., Berger F; Clinatec INSERM UA01, Centre de Recherche Edmond J. Safra, CEA Grenoble, Grenoble 38054, France., Lahrech H; Clinatec INSERM UA01, Centre de Recherche Edmond J. Safra, CEA Grenoble, Grenoble 38054, France.
Jazyk: angličtina
Zdroj: Medical physics [Med Phys] 2015 Nov; Vol. 42 (11), pp. 6369-75.
DOI: 10.1118/1.4932218
Abstrakt: Purpose: In preclinical studies, the Rapid-Steady-State-T1 (RSST1) MRI method has advantages over conventional MRI methods for blood volume fraction (BVf) mapping, since after contrast agent administration, the BVf is directly quantifiable from the signal amplitude corresponding to the vascular equilibrium magnetization. This study focuses on its clinical implementation and feasibility.
Methods: Following sequence implementation on clinical Philips Achieva scanners, the RSST1-method is assessed at 1.5 and 3 T in the follow-up examination of neurooncological patients receiving 0.1-0.2 mmol/kg Gd-DOTA to determine the threshold dose needed for cerebral BVf quantification. Confounding effects on BVf quantification such as transendothelial water exchange, transverse relaxation, and contrast agent extravasation are evaluated.
Results: For a dose≥0.13 mmol/kg at 1.5 T and ≥0.16 mmol/kg at 3 T, the RSST1-signal time course in macrovessels and brain tissue with Gd-DOTA impermeable vasculature reaches a steady state at maximum amplitude for about 8 s. In macrovessels, a BVf of 100% was obtained validating cerebral microvascular BVf quantification (3.5%-4.5% in gray matter and 1.5%-2.0% in white matter). In tumor tissue, a continuously increasing signal is detected, necessitating signal modeling for tumor BVf calculation.
Conclusions: Using approved doses of Gd-DOTA, the steady state RSST1-signal in brain tissue is reached during the first pass and corresponds to the BVf. The first-pass duration is sufficient to allow accurate BVf quantification. The RSST1-method is appropriate for serial clinical studies since it allows fast and straightforward BVf quantification without arterial input function determination. This quantitative MRI method is particularly useful to assess the efficacy of antiangiogenic agents.
Databáze: MEDLINE