Anxiolytic and Antidepressant Effects of Divaza and Brizantin.

Autor: Yakovleva NN; Materia Medica Holding, Moscow, Russia. guryanovann@materiamedica.ru., Voronina TA; Materia Medica Holding, Moscow, Russia., Suslov NI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia., Ertuzun IA; Materia Medica Holding, Moscow, Russia., Molodavkin GM; Materia Medica Holding, Moscow, Russia., Poseva VI; Materia Medica Holding, Moscow, Russia., Andreeva VV; Materia Medica Holding, Moscow, Russia., Dugina YL; Materia Medica Holding, Moscow, Russia., Putilovskii MA; Materia Medica Holding, Moscow, Russia., Epshtein OI; Materia Medica Holding, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Oct; Vol. 159 (6), pp. 753-6. Date of Electronic Publication: 2015 Oct 30.
DOI: 10.1007/s10517-015-3067-6
Abstrakt: The anxiolytic and antidepressant activities of complex preparations divaza and brizantin containing antibodies to brain-specific protein S100 were estimated using Vogel conflict test and Nomura forced swimming test. Course treatment (5 days) of brizantin in a dose of 2.5 ml/kg and divaza in a dose of 7.5 ml/kg significantly increased punished drinking in the Vogel conflict test in comparison with the control. Both drugs also improved general emotional behavior during training prior to the test procedure. Brizantin and divaza in a dose of 7.5 ml/kg increased the number of wheel revolutions in the Nomura forced swimming test in comparison with the control; the effect of divaza was more pronounced. High correlation coefficients between the number of wheel revolutions during the first and second 5-min sessions are also indicative of antidepressant action of divaza and brizantin.
Databáze: MEDLINE
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