Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis.

Autor: Hammad A; a Pediatric Nephrology Unit, Mansoura University Children's Hospital , Mansoura , Egypt ., Mosaad YM; b Clinical Immunology Unit, Clinical Pathology Department & Mansoura Research Center for Cord Stem Cells (MARC_CSC), Faculty of Medicine, Mansoura University , Mansoura , Egypt ., Hammad EM; c Rheumatology and Rehabilitation Department, Mansoura University Hospital , Mansoura , Egypt ., Elhanbly S; d Dermatology and Andrology Department, Mansoura Faculty of Medicine , Mansoura , Egypt ., El-Bassiony SR; c Rheumatology and Rehabilitation Department, Mansoura University Hospital , Mansoura , Egypt ., Al-Harrass MF; b Clinical Immunology Unit, Clinical Pathology Department & Mansoura Research Center for Cord Stem Cells (MARC_CSC), Faculty of Medicine, Mansoura University , Mansoura , Egypt ., Eid R; a Pediatric Nephrology Unit, Mansoura University Children's Hospital , Mansoura , Egypt ., Sharaf Eldein OA; e Clinical Hematology Unit, Clinical Pathology Department, Faculty of Medicine, Mansoura University , Mansoura , Egypt ., Alsawah GA; f Pediatric Cardiology Unit and., Yahia S; g Genetics Unit, Mansoura University Children's Hospital , Mansoura , Egypt , and., Fawzy IM; h Laboratory Medicine Department , Mansoura Fever Hospital, Ministry of Health , Mansoura , Egypt.
Jazyk: angličtina
Zdroj: Autoimmunity [Autoimmunity] 2016; Vol. 49 (1), pp. 31-40. Date of Electronic Publication: 2015 Oct 30.
DOI: 10.3109/08916934.2015.1101071
Abstrakt: Unlabelled: There are no reports about the association of interleukin (IL)-17A and IL-17F gene polymorphism and susceptibility to pediatric systemic lupus erythematosus (pSLE).
Objective: To examine the possible role of IL-17A rs2275913, IL-17F rs763780 and rs2397084 polymorphisms as risk factors for pSLE in a cohort of Egyptian children and to investigate their association with the clinico-pathological features including lupus nephritis (LN).
Methods: Typing of IL-17A and IL-17F polymorphisms was done using restriction fragment length polymorphism for 115 children with SLE and 259 age- and sex-matched healthy controls.
Results: No significant differences were found between pSLE patients and healthy controls for the allele and genotype frequencies of IL-17A rs2275913, IL-17F rs763780 and rs2397084 (p > 0.05). However, the combined genotype GGAGAA and the haplotype GGA had significant association with pSLE (pc = 0.042 and <0.001, respectively). The AA genotype of IL-17F rs763780 is more frequent in female patients (p = 0.002) and the AA genotype of IL-17F rs2397084 is more associated with positivity of ds-DNA (p = 0.007). No more associations were found for the demographic and clinical data of pSLE patients including risk of LN development, risk of non-remission, overall survival, activity and chronicity indices.
Conclusion: The GGAGAA combined genotype and the GGA haplotype of IL-17A rs2275913, IL-17F rs763780 and rs2397084 can be considered risk factors for the development of SLE in Egyptian children. IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
Databáze: MEDLINE
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