Gonococcal infections in Austria: a long-term observation of prevalence and resistance profiles from 1999 to 2014.

Autor: Stary A; Outpatient Clinic and Other Venereal/Dermatologic Diseases, Vienna, Austria., Heller-Vitouch C; Outpatient Clinic and Other Venereal/Dermatologic Diseases, Vienna, Austria., Binder M; Outpatient Clinic for the Diagnosis and Treatment of Sexually Transmitted Diseases - Municipal Department 15, Vienna, Austria., Geusau A; Division of Immunology, Allergy, and Infectious Diseases, Department of Dermatology, University Medical Center Vienna, Vienna, Austria., Stary G; Division of Immunology, Allergy, and Infectious Diseases, Department of Dermatology, University Medical Center Vienna, Vienna, Austria., Rappersberger K; Department of Dermatology and Venereology, Rudolfstiftung Hospital, Vienna, Austria., Komericki P; Department of Dermatology and Venereology, University Medical Center Graz, Graz, Austria., Hoepfl R; Department of Dermatology and Venereology, University Medical Center Innsbruck, Innsbruck, Austria., Haller M; Outpatient Clinic and Other Venereal/Dermatologic Diseases, Vienna, Austria.
Jazyk: angličtina
Zdroj: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2015 Nov; Vol. 13 (11), pp. 1136-45.
DOI: 10.1111/ddg.12816
Abstrakt: Background and Objectives: The increase in minimum inhibitory concentrations (MICs) of cephalosporins for Neisseria gonorrhoeae has given rise to concerns regarding potentially untreatable gonococcal infections. The goal was to ascertain the prevalence of gonorrhea in a Viennese patient group and determine resistance patterns. Another objective was to evaluate resistance profiles and MIC values of gonococcal isolates in an Austria-wide surveillance project.
Patients and Methods: From 1999 to 2014, 350,000 individuals were tested for gonococci at the Viennese Outpatient Clinic. In addition, from 2010 to 2014, the MICs of recommended antibiotics was determined in 3,584 gonococcal isolates, initially by agar dilution and breakpoint determination, and, from 2012 onwards, by Etest®.
Results: During the observation period, the prevalence of gonorrhea increased eightfold, with a significantly greater number of quinolone, penicillin, and tetracycline- resistant strains. In gonococcal strains isolated from across Austria, there was an increase in cefixime and ceftriaxone MICs toward breakpoints. Twenty-one isolates showed cefixime resistance, and while there was an increase in azithromycin resistance from 0.9 % (2013) to 3.2 % (2014), no resistance to ceftriaxone was observed.
Conclusion: Currently, there is no imminent risk of untreatable gonorrhea in Austria. However, continuing the use of gonococcal cultures as a diagnostic tool for establishing resistance profiles is essential in order to monitor trends in the development of Neisseria (N.) gonorrhoeae resistance.
(© 2015 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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