Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats.

Autor: Gimenes C; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil ; Sagrado Coração University, Bauru, SP, Brazil., Gimenes R; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Rosa CM; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Xavier NP; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Campos DH; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Fernandes AA; Department of Chemistry and Biochemistry, Institute of Biosciences, São Paulo State University (UNESP), Brazil., Cezar MD; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Guirado GN; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Cicogna AC; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Takamoto AH; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Okoshi MP; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil., Okoshi K; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil.
Jazyk: angličtina
Zdroj: Journal of diabetes research [J Diabetes Res] 2015; Vol. 2015, pp. 457848. Date of Electronic Publication: 2015 Oct 05.
DOI: 10.1155/2015/457848
Abstrakt: Unlabelled: We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary diabetes (DM-Sed), and exercised diabetes (DM-Ex). Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m/min, 18 min/day. Myocardial function was evaluated in left ventricular (LV) papillary muscles and oxidative stress in LV tissue. Statistical analysis was given by ANOVA or Kruskal-Wallis. Echocardiogram showed diabetic groups with higher LV diastolic diameter-to-body weight ratio and lower posterior wall shortening velocity than controls. Left atrium diameter was lower in DM-Ex than DM-Sed (C-Sed: 5.73 ± 0.49; C-Ex: 5.67 ± 0.53; DM-Sed: 6.41 ± 0.54; DM-Ex: 5.81 ± 0.50 mm; P < 0.05 DM-Sed vs C-Sed and DM-Ex). Papillary muscle function was depressed in DM-Sed compared to C-Sed. Exercise attenuated this change in DM-Ex. Lipid hydroperoxide concentration was higher in DM-Sed than C-Sed and DM-Ex. Catalase and superoxide dismutase activities were lower in diabetics than controls and higher in DM-Ex than DM-Sed. Glutathione peroxidase activity was lower in DM-Sed than C-Sed and DM-Ex.
Conclusion: Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats.
Databáze: MEDLINE
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