Prevalence of Vitamin D Deficiency in Patients with Bone Metastases and Multiple Myeloma.
| Autor: | Maier GS; University Hospital of Orthopaedic Surgery, Pius-Hospital, Carl-von-Ossietzky-University, Oldenburg, Germany gerrit.maier@uni-oldenburg.de., Horas K; ANZAC Research Institute, University of Sydney at Concord, Sydney, NSW, Australia., Kurth AA; Department of Orthopaedic Surgery, Themistocles Gluck Hospital, Ratingen, Germany., Lazovic D; University Hospital of Orthopaedic Surgery, Pius-Hospital, Carl-von-Ossietzky-University, Oldenburg, Germany., Seeger JB; Department of Orthopaedic Surgery, Justus-Liebig-University, Giessen, Germany., Maus U; University Hospital of Orthopaedic Surgery, Pius-Hospital, Carl-von-Ossietzky-University, Oldenburg, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Anticancer research [Anticancer Res] 2015 Nov; Vol. 35 (11), pp. 6281-5. |
| Abstrakt: | Background/aim: Breast and prostate cancer are amongst the most prevalent malignancies globally and up to 40% of patients will develop metastatic disease, particularly to the skeleton. Multiple myeloma is the most common cancer to affect bone with up to 90% of patients developing bone lesions. Although several studies demonstrated that endocrine changes such as vitamin D deficiency promote secondary cancer growth in bone, relatively few have reported its prevalence. For this reason, the purpose of the present study was to evaluate the prevalence of hypovitaminosis D in patients with bone metastases and multiple myeloma. Patients and Methods: Serum 25-OH-D levels of patients with metastatic bone disease were measured on admission. Statistical analyses was performed to evaluate for possible confounders of hypo-vitaminosis D. Results: We found a widespread and alarming rate of vitamin D deficiency in patients with metastatic bone disease and multiple myeloma. Of note, patients with bone metastases due to breast cancer, prostate cancer and multiple myeloma rarely reached sufficient serum 25-OH-D levels. Conclusion: It is of utmost clinical importance to assess vitamin D levels in cancer patients, especially in those with, or at high risk of developing metastatic bone disease. (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.) |
| Databáze: | MEDLINE |
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