Characterization of Lamprey IL-17 Family Members and Their Receptors.

Autor:	Han Q; Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; and., Das S; Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; and., Hirano M; Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; and., Holland SJ; Department of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany., McCurley N; Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; and., Guo P; Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; and., Rosenberg CS; Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; and., Boehm T; Department of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany., Cooper MD; Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; and max.cooper@emory.edu.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Dec 01; Vol. 195 (11), pp. 5440-51. Date of Electronic Publication: 2015 Oct 21.
DOI:	10.4049/jimmunol.1500892
Abstrakt:	IL-17 is an ancient cytokine implicated in a variety of immune defense reactions. We identified five members of the sea lamprey IL-17 family (IL-17D.1, IL-17D.2, IL-17E, IL-17B, and IL-17C) and six IL-17R genes (IL-17RA.1, IL-17RA.2, IL-17RA.3, IL-17RF, IL-17RE/RC, and IL-17RD), determined their relationship with mammalian orthologs, and examined their expression patterns and potential interactions to explore their roles in innate and adaptive immunity. The most highly expressed IL-17 family member is IL-17D.1 (mammalian IL-17D like), which was found to be preferentially expressed by epithelial cells of skin, intestine, and gills and by the two types of lamprey T-like cells. IL-17D.1 binding to rIL-17RA.1 and to the surface of IL-17RA.1-expressing B-like cells and monocytes of lamprey larvae was demonstrated, and treatment of lamprey blood cells with rIL-17D.1 protein enhanced transcription of genes expressed by the B-like cells. These findings suggest a potential role for IL-17 in coordinating the interactions between T-like cells and other cells of the adaptive and innate immune systems in jawless vertebrates. (Copyright © 2015 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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