Clinical presentation of intraocular retinoblastoma; 5-year hospital-based registry in Egypt.

Autor:	El Zomor H; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Egyptian National Cancer Institute, Cairo University, Cairo, Egypt., Nour R; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt., Alieldin A; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Research Institute of Ophthalmology, Cairo, Egypt., Taha H; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Egyptian National Cancer Institute, Cairo University, Cairo, Egypt., Montasr MM; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Tanta University Medical School, Egypt., Moussa E; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Faculty of Medicine, Menofeyia University, Shebin Elkom, Egypt., El Nadi E; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Beni sweif University Medical School, Beni sweif, Egypt., Ezzat S; National Liver Institute, Menofeyia University, Shebin Elkom, Egypt., Alfaar AS; Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Cairo University School of Medicine, Cairo, Egypt. Electronic address: ahmadsfar@gmail.com.
Jazyk:	angličtina
Zdroj:	Journal of the Egyptian National Cancer Institute [J Egypt Natl Canc Inst] 2015 Dec; Vol. 27 (4), pp. 195-203. Date of Electronic Publication: 2015 Oct 17.
DOI:	10.1016/j.jnci.2015.09.002
Abstrakt:	Purpose: To study the presenting signs of Retinoblastoma in Egypt at Egypt's main pediatric oncology referral center. Methods: This is a prospective descriptive study (hospital-based registry) conducted at Children's Cancer Hospital Egypt between July 2007 and December 2012. Results: Out of 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease at presentation. One hundred thirty-nine (57%) patients presented with unilateral disease, while 105 (43%) suffered bilateral disease. The mean age at presentation was 20.6 ± 17 months, averaging 18.87 ± 11.76 months for bilateral and 25.72 ± 18.78 months for unilateral disease. The most common clinical presentation was leukocoria in 180 (73.8%) patients, strabismus in 32 (13.1%) patients and decreased visual acuity in 12 (4.9%) patients. Group D and E disease represented 62% of all affected eyes. Patients with advanced disease (Group C-E) had longer duration of symptoms. Conclusion: In Egypt, retinoblastoma patients present more frequently with advanced disease. There is an ever-increasing need to develop a national team dedicated to studying disease significance and formulating a national awareness program. (Copyright © 2015 The Authors. Production and hosting by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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