A look into the evolution of Epstein-Barr virus-induced lymphoproliferative disorders: a case study.

Autor:	Ambrosio MR; From the Department of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy;, Rocca BJ; From the Department of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy; Pathology Unit, Ospedale di circolo di Busto Arsizio, Varese, Italy; and., Ginori A; From the Department of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy;, Mourmouras V; From the Department of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy;, Amato T; From the Department of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy;, Vindigni C; Section of Pathology, 'Azienda Ospedaliera Universitaria Senese,' Siena, Italy., Lazzi S; Section of Pathology, 'Azienda Ospedaliera Universitaria Senese,' Siena, Italy., Leoncini L; From the Department of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy; lorenzo.leoncini@dbm.unisi.it.
Jazyk:	angličtina
Zdroj:	American journal of clinical pathology [Am J Clin Pathol] 2015 Nov; Vol. 144 (5), pp. 817-22.
DOI:	10.1309/AJCP2G0VKTKPNPRR
Abstrakt:	Objectives: Epstein-Barr virus (EBV)-induced lymphoproliferative disorders (LPDs) are lymphoid proliferations arising as a result of the loss of an effective EBV-specific cytotoxic T-cell response. LPDs may occur for primary or acquired impairment of the immune system, as well as in some persons without documented immunodeficiency. Methods: In this article, we describe the case of a human immunodeficiency virus-positive patient affected by an EBV-LPD of the stomach who developed a nodal diffuse large B-cell lymphoma with complex morphologic and molecular features. Results: GeneScan analysis of the gastric specimen identified two different heavy-chain immunoglobulin gene (IGH) rearrangements characterized by a dominant peak of 285 base pairs (bp) in length and a smaller peak of 266 bp in length. In the lymph node sample, IGH evaluation also demonstrated two different peaks; however, the main peak corresponded to the minor peak detected in the EBV-LPD specimen at the diagnosis. In addition, a monoclonal immunoglobulin light chain gene (IGL) rearrangement was also found. We also demonstrated that the major peak in the stomach corresponded to the EBV-positive population observed in the histologic sections. Conclusions: This case may provide additional insights to better understanding the "hit-and-run" role for EBV in lymphomagenesis. However, we could not exclude that our findings represent the co-occurrence of two unrelated B-cell neoplasms rather than a progression from an EBV-positive neoplasm to an EBV-negative one. (Copyright© by the American Society for Clinical Pathology.)
Databáze:	MEDLINE
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