PREVALENCE OF INCIDENTAL GALLBLADDER CANCER IN A TERTIARY-CARE HOSPITAL FROM PERNAMBUCO, BRAZIL.

Autor:	Martins-Filho ED; Departamento de Cirurgia, Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, BR., Batista TP; Departamento de Cirurgia, Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, BR., Kreimer F; Departamento de Cirurgia, Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, BR., Martins AC; Departamento de Cirurgia, Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, BR., Iwanaga TC; Departamento de Cirurgia, Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, BR., Leão Cde S; Departamento de Cirurgia, Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, BR.
Jazyk:	angličtina
Zdroj:	Arquivos de gastroenterologia [Arq Gastroenterol] 2015 Jul-Sep; Vol. 52 (3), pp. 247-9.
DOI:	10.1590/S0004-28032015000300017
Abstrakt:	Background: Gallbladder cancer is sometimes incidentally uncovered following cholecystectomy for gallstones diseases. The supposed highly variable prevalence of incidental gallbladder cancer through our country is unknown. Objective: To explore the prevalence of incidental gallbladder cancer in our tertiary-care hospital. Methods: A cross-sectional study was carried out on patients who consecutively underwent cholecystectomy due to gallstones disease at Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira - FPS/IMIP, from January, 2007 to December, 2010. Data on incidental gallbladder cancer patients were explored for prevalence estimation and description of our experience with the management of this malignancy. Results: Our analysis involved 2018 patients with a marked predominance of women (n=1.697; 84.1%) over men (n=321; 15.9%). The 3-year prevalence estimate of 0.34% was recorded for incidental gallbladder cancer in our sample. Regarding tumor staging, there were 1 T1a, 1 T1b, and 5 T2 adenocarcinoma tumors. Laparoscopic cholecystectomy alone was performed for the T1a tumor, and additional radical surgery was performed in five others. One patient presented metastatic disease at the time of repeat surgery. The final pathology revealed residual/additional disease in all T2 tumors after radical surgery whereas the T1b patient underwent a salvage Whipple's procedure due to a secondary distal cholangiocarcinoma. The patient with T1a tumor is alive after 3-year follow-up but all of the others died because of disease recurrence/progression up to 12 months. Conclusion: This study confirms the poor prognosis of Gallbladder cancer even when incidentally diagnosed following cholecystectomy and supposes a 3-year prevalence estimate of 0.34% for incidental gallbladder cancer in our Center from Pernambuco State, Brazil.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu