ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON.

Autor:	Santos KN; Laboratório de Patologia Clínica das Doenças Tropicais, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, PA, BR., Almeida MK; Laboratório de Patologia Clínica das Doenças Tropicais, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, PA, BR., Fecury AA; Laboratório de Patologia Clínica das Doenças Tropicais, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, PA, BR., Costa CA; Laboratório de Patologia Clínica das Doenças Tropicais, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, PA, BR., Martins LC; Laboratório de Patologia Clínica das Doenças Tropicais, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, PA, BR.
Jazyk:	angličtina
Zdroj:	Arquivos de gastroenterologia [Arq Gastroenterol] 2015 Jul-Sep; Vol. 52 (3), pp. 222-7.
DOI:	10.1590/S0004-28032015000300013
Abstrakt:	Background: The hepatitis C virus has been recognized as the leading cause of chronic liver disease in the world. Host genetic factors have been implicated in the persistence of hepatitis C virus infection. Single nucleotide polymorphisms at positions -607 C/A (rs1946518) and -137 G/C (rs187238) in the IL-18 gene promoter have been suggested to be associated with delayed hepatitis C virus clearance and persistence of the disease. Objective: Identify these polymorphisms in a population infected with hepatitis C virus from the Brazilian Amazon region. Methods: In a cross-sectional analytical study conducted in Belém, Pará, Brazil, 304 patients infected with hepatitis C virus were divided into two groups: group A, patients with persistent infection; group B, patients with spontaneous clearance. The control group consisted of 376 volunteers not infected with hepatitis C virus. Samples were analyzed by RT-PCR for the detection of viral RNA and by RFLP-PCR to evaluate the presence of the -137 G/C and -607 C/A IL-18 gene promoter polymorphisms. Results: Comparison of polymorphism allele frequencies between the patient and control groups showed a higher frequency of allele C at position -607 among patients (P=0.02). When the association between the polymorphisms and viral infection was analyzed, patients carrying genotype C/A at position -607 were found to be at higher risk of persistent hepatitis C virus infection (P=0.03). Conclusion: The present results suggest a possible role of the -607 IL-18 gene promoter polymorphism in the pathogenesis of hepatitis C virus infection.
Databáze:	MEDLINE
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