An in vivo transcriptome data set of natural antisense transcripts from Plasmodium falciparum clinical isolates.

Autor:	Subudhi AK; Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, India., Boopathi PA; Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, India., Garg S; Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, India., Middha S; Department of Medicine, S.P. Medical College, Bikaner, Rajasthan, India., Acharya J; Department of Medicine, S.P. Medical College, Bikaner, Rajasthan, India., Pakalapati D; Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, India., Saxena V; Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, India., Aiyaz M; Genotypic Technology Pvt. Ltd., Bangalore, India., Orekondy HB; Genotypic Technology Pvt. Ltd., Bangalore, India., Mugasimangalam RC; Genotypic Technology Pvt. Ltd., Bangalore, India., Sirohi P; Department of Medicine, S.P. Medical College, Bikaner, Rajasthan, India., Kochar SK; Department of Medicine, S.P. Medical College, Bikaner, Rajasthan, India., Kochar DK; Rajasthan University of Health Sciences, Jaipur, Rajasthan, India., Das A; Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, India.
Jazyk:	angličtina
Zdroj:	Genomics data [Genom Data] 2014 Oct 29; Vol. 2, pp. 393-5. Date of Electronic Publication: 2014 Oct 29 (Print Publication: 2014).
DOI:	10.1016/j.gdata.2014.10.010
Abstrakt:	Antisense transcription is pervasive among biological systems and one of the products of antisense transcription is natural antisense transcripts (NATs). Emerging evidences suggest that they are key regulators of gene expression. With the discovery of NATs in Plasmodium falciparum, it has been suggested that these might also be playing regulatory roles in this parasite. However, all the reports describing the diversity of NATs have come from parasites in culture condition except for a recent study published by us. In order to explore the in vivo diversity of NATs in P. falciparum clinical isolates, we performed a whole genome expression profiling using a strand-specific 244 K microarray that contains probes for both sense and antisense transcripts. In this report, we describe the experimental procedure and analysis thereof of the microarray data published recently in Gene Expression Omnibus (GEO) under accession number GSE44921. This published data provide a wealth of information about the prevalence of NATs in P. falciparum clinical isolates from patients with diverse malaria related disease conditions. Supplementary information about the description and interpretation of the data can be found in a recent publication by Subudhi et al. in Experimental Parasitology (2014).
Databáze:	MEDLINE
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