Effects of administration of a synthetic low molecular weight/low molar substitution hydroxyethyl starch solution in healthy neonatal foals.

Autor:	Hepworth-Warren KL; Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA., Wong DM; Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA., Hay-Kraus BL; Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA., Wang C; Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA., Sun Y; Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Jazyk:	angličtina
Zdroj:	The Canadian veterinary journal = La revue veterinaire canadienne [Can Vet J] 2015 Oct; Vol. 56 (10), pp. 1069-74.
Abstrakt:	This study compared the effects of IV administration of isotonic fluid therapy and colloidal fluid therapy in healthy neonatal foals. Fifteen healthy neonatal foals were used in a randomized blinded prospective clinical study. Foals were randomly assigned to receive a bolus of 20 mL/kg of tetrastarch (TES) or balanced crystalloid solution. Vital parameters, colloid osmotic pressure (COP), and various clinicopathologic variables were assessed prior to infusion and at various time points up to 120 h after infusion. The treatment group (TES) had a significant increase in both COP and percentage increase in COP at 1 and 3 h. The COP was significantly lower than baseline at 3 h in the control group. No significant changes were observed in coagulation parameters in either group. Tetrastarch was effective in increasing COP for 3 h after infusion and had no notable adverse clinical effects in this group of healthy foals. Further studies are warranted regarding optimal dosing and effects in clinically ill foals.
Databáze:	MEDLINE
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