[Potential of the zebrafish model to study congenital muscular dystrophies].

Autor:	Ryckebüsch L; Division of biological sciences, university of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0380, La Jolla, États-Unis.
Jazyk:	francouzština
Zdroj:	Medecine sciences : M/S [Med Sci (Paris)] 2015 Oct; Vol. 31 (10), pp. 912-9. Date of Electronic Publication: 2015 Oct 19.
DOI:	10.1051/medsci/20153110018
Abstrakt:	In order to better understand the complexity of congenital muscular dystrophies (CMD) and develop new strategies to cure them, it is important to establish new disease models. Due to its numerous helpful attributes, the zebrafish has recently become a very powerful animal model for the study of CMD. For some CMD, this vertebrate model is phenotypically closer to human pathology than the murine model. Over the last few years, researchers have developed innovative techniques to screen rapidly and on a large scale for muscle defects in zebrafish. Furthermore, new genome editing techniques in zebrafish make possible the identification of new disease models. In this review, the major attributes of zebrafish for CMD studies are discussed and the principal models of CMD in zebrafish are highlighted. (© 2015 médecine/sciences – Inserm.)
Databáze:	MEDLINE
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