Bleeding Diathesis in Fawn Hooded Rats-Possible Implications for Invasive Procedures and Refinement Strategies.
| Autor: | Schaap MW; Division of Animal Welfare and Laboratory Animal Science, Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands. M.schaap@uu.nl., van Oostrom H; School of Veterinary Sciences, Bristol University, Langford, Bristol BS40 5DU, UK. hugo.vanoostrom@bristol.ac.uk., Arndt SS; Division of Animal Welfare and Laboratory Animal Science, Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands. S.S.Arndt@uu.nl., Hellebrekers LJ; Division of Animal Welfare and Laboratory Animal Science, Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands. L.J.Hellebrekers@uu.nl. |
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| Jazyk: | angličtina |
| Zdroj: | Animals : an open access journal from MDPI [Animals (Basel)] 2015 Apr 24; Vol. 5 (2), pp. 270-5. Date of Electronic Publication: 2015 Apr 24. |
| DOI: | 10.3390/ani5020270 |
| Abstrakt: | The Fawn hooded (FH) rat is commonly used in biomedical research. It is widely acknowledged that the FH rat has a bleeding disorder; leading to abundant bleedings. Although this bleeding disorder is investigated to model the storage pool defect; its impact on commonly performed invasive laboratory procedures has not yet been described. Our research group experienced clinically significant consequences of this bleeding disorder following invasive procedures (including intraperitoneal injections and neurocranial surgery) in the Rjlbm: FH stock. The clinical consequences of the surgical and anesthetic protocols applied; are described including the subsequent procedural refinements applied to minimize the impact of this disorder. It is strongly recommended to take the bleeding diathesis into account when performing invasive procedures in FH rats and to apply the suggested refinement of procedures. |
| Databáze: | MEDLINE |
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