Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity.

Autor:	Mori S; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. smori@mail.chem.tamu.edu., Williams H; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. williams@cbnmr.chem.tamu.edu., Cagle D; Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA. dcagle@my.hpu.edu., Karanovich K; Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA. kkaranovich@gmail.com., Horgen FD; Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA. dhorgen@hpu.edu., Smith R III; Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA. ROSmith@cvm.tamu.edu., Watanabe CM; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. watanabe@mail.chem.tamu.edu.
Jazyk:	angličtina
Zdroj:	Marine drugs [Mar Drugs] 2015 Oct 09; Vol. 13 (10), pp. 6274-90. Date of Electronic Publication: 2015 Oct 09.
DOI:	10.3390/md13106274
Abstrakt:	A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.
Databáze:	MEDLINE
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