| Autor: |
Oh JH; Departments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea., Jung SH; Departments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea., Hong SJ; Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea., Rhyu MG; Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cancer prevention [J Cancer Prev] 2015 Sep; Vol. 20 (3), pp. 172-8. |
| DOI: |
10.15430/JCP.2015.20.3.172 |
| Abstrakt: |
Stomach cancer remains, stubbornly, highly prevalent in East Asia. Still, stomach cancer has few biomarkers by which it can be predicted. Helicobacter pylori infection, a known carcinogen of stomach cancer, usually goes undetected prior to cancer diagnosis, due to the poor mucosal environments that its related gastric atrophy causes. We propose, herein, an endoscopic-biopsy-based cancer-predicting DNA methylation marker. We semi-quantitatively examined the methylation-variable sites near the CpG-island margins by radioisotope-labeling methylation-specific polymerase chain reaction in association with H. pylori, which increases age-related over-methylation in CpG islands of gastric mucosa. These age-related methylation patterns of the transitional-CpG sites are proposed as useful surrogate markers for stomach cancer. It would be helpful for setting the optimal screening interval for high-risk subjects as well as for estimating the prognosis and the predictability for recurrence of early gastric cancer in patients having undergone endoscopic submucosal dissection. New screening-interval guidelines for gastric cancer should be suggested considering individual risk based on age, severity of atrophy, H. pylori status, and DNA methylation pattern. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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