Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders.
| Autor: | Fisher ML; Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA., Loukola A; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kaprio J; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland., Turner JR; Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA. Electronic address: jiturner@sccp.sc.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | International review of neurobiology [Int Rev Neurobiol] 2015; Vol. 124, pp. 113-31. Date of Electronic Publication: 2015 Sep 16. |
| DOI: | 10.1016/bs.irn.2015.07.006 |
| Abstrakt: | Smoking is currently the leading cause of preventable death in the United States and is responsible for over four million deaths annually worldwide. Therefore, there is a vast clinical unmet need with regards to therapeutics targeting smoking cessation. This is even more apparent when examining smokers co-morbid with psychiatric illness, as rates of smoking in this population are ~4× higher than in the general population. Examining common genetic and molecular signaling pathways impinging upon both smoking behavior and psychiatric illness will lead to a better understanding of co-morbid disorders and potential development of novel therapeutics. Studies have implicated the Neuregulin Signaling Pathway in the pathophysiology of a number of psychiatric illnesses. Additionally, recent studies have also shown an association between the Neuregulin Signaling Pathway and smoking behaviors. This review outlines basic mechanisms of the Neuregulin Signaling Pathway and how it may be exploited for precision medicine approaches in treating nicotine dependence and mental illness. (© 2015 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|