Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells.

Autor: Albegova DZ; Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Kamkina OV; Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. bigbeaver-90@mail.ru., Pavlova SI; I. N. Ulyanov, Chuvash State University, Cheboksary, Russia., Albegova ZhK; North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, Vladikavkaz, Russia., Laptev OS; D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia., Kozlov IG; Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.; D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Sep; Vol. 159 (5), pp. 626-8. Date of Electronic Publication: 2015 Oct 15.
DOI: 10.1007/s10517-015-3031-5
Abstrakt: An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4(+) T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit.
Databáze: MEDLINE
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