Efficacy of radioembolization according to tumor morphology and portal vein thrombosis in intermediate-advanced hepatocellular carcinoma.

Autor:	Golfieri R; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Mosconi C; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Cappelli A; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Giampalma E; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Galaverni MC; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Pettinato C; Medical Physics Unit, Radiology Unit, S Orsola-Malpighi Hospital, Bologna, Italy., Renzulli M; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Monari F; Radiation Oncology Unit, Radiology Unit, S Orsola-Malpighi Hospital, Bologna, Italy., Angelelli B; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Pini P; Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy., Terzi E; Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy., Ascanio S; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Garzillo G; Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy., Piscaglia F; Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy., Bolondi L; Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy., Trevisani F; Department of Medical & Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Jazyk:	angličtina
Zdroj:	Future oncology (London, England) [Future Oncol] 2015; Vol. 11 (23), pp. 3133-42. Date of Electronic Publication: 2015 Oct 15.
DOI:	10.2217/fon.15.267
Abstrakt:	Purpose: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). Methods: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. Results: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. Conclusion: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
Databáze:	MEDLINE
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