Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women.

Autor:	Cruvinel Wde M; School of Medical, Pharmaceutical and Biomedical Sciences, Pontifícia Universidade Católica de Goiás, Goiás, GO, BR., Mesquita Júnior D; Division of Rheumatology, Universidade Federal de São Paulo, São Paulo, SP, BR., Araújo JA; Division of Rheumatology, Universidade Federal de São Paulo, São Paulo, SP, BR., Samazi KC; Division of Clinical Immunology and Allergy, Universidade de São Paulo, São Paulo, SP, BR., Kállas EG; Division of Clinical Immunology and Allergy, Universidade de São Paulo, São Paulo, SP, BR., Cendoroglo MS; Division of Geriatrics, Universidade Federal de São Paulo, São Paulo, SP, BR., Andrade LE; Division of Rheumatology, Universidade Federal de São Paulo, São Paulo, SP, BR.
Jazyk:	angličtina
Zdroj:	Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2015 Aug; Vol. 61 (4), pp. 329-35.
DOI:	10.1590/1806-9282.61.04.329
Abstrakt:	Introduction: aging is associated with several immunologic changes. Regulatory (Treg) and effector T cells are involved in the pathogenesis of infectious, neoplastic, and autoimmune diseases. Little is known about the effects of aging on the frequency and function of these T cell subpopulations. Methods: peripheral blood mononuclear cells (PBMC) were obtained from 26 young (under 44 years old) and 18 elderly (above 80 years old) healthy women. T cell subpopulations were analyzed by flow cytometry. Results: elderly individuals had lower frequency of several activated effector T cell phenotypes as compared with young individuals: CD3+CD4+CD25+ (3.82±1.93 versus 9.53±4.49; p<0.0001); CD3+CD4+CD25+CD127+(2.39±1.19 versus 7.26±3.84; p<0.0001); CD3+CD4+CD25+ (0.41±0.22 versus 1.86±0.85, p<0.0001); and CD3+CD4+CD25highCD127+(0.06±0.038 versus 0.94±0.64, p<0.0001). Treg (CD3+CD4+CD25+CD127øFoxp3+) presented lower frequency in elderly individuals as compared to young adults (0.34±0.18 versus 0.76±0.48; p=0.0004) and its frequency was inversely correlated with age in the whole group (r=-0.439; p=0.013). The elderly group showed higher frequency of two undefined CD25øFoxp3+ phenotypes: CD3+CD4+CD25øFoxp3+(15.05±7.34 versus 1.65±1.71; p<0.0001) and CD3+CD4+CD25øCD127øFoxp3+(13.0±5.52 versus 3.51±2.87; p<0.0001). Conclusions: the altered proportion of different T cell subsets herein documented in healthy elderly women may be relevant to the understanding of the immunologic behavior and disease susceptibility patterns observed in geriatric patients.
Databáze:	MEDLINE
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