Chronic psychological stress and its impact on the development of aggressive breast cancer.
| Autor: | Cormanique TF; Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., Almeida LE; Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., Rech CA; Hospital do Câncer de Francisco Beltrão, Francisco Beltrão, PR, Brazil., Rech D; Hospital do Câncer de Francisco Beltrão, Francisco Beltrão, PR, Brazil., Herrera AC; Pontifícia Universidade Católica do Paraná, Londrina, PR, Brazil., Panis C; Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil. |
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| Jazyk: | English; Portuguese |
| Zdroj: | Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2015 Jul-Sep; Vol. 13 (3), pp. 352-6. |
| DOI: | 10.1590/S1679-45082015AO3344 |
| Abstrakt: | Objective: To investigate the clinicopathological findings of women diagnosed with breast cancer and study the impact of chronic psychological stress on the pathological characteristics of these tumors. Methods: We investigated a cohort composed of women diagnosed with breast cancer and divided into two groups. One group was categorized as presenting with chronic psychological stress (by using the Self-Reporting Questionnaire - SRQ-20). Another group of women with breast cancer, but with no previous history of chronic psychological stress, comprised the Control Group. Clinical and pathological data were assessed. Results: Women presenting with a history of chronic distress were significantly overweight when compared to the Control Group. Furthermore, it was observed that these stressed women also had a significant percentage of aggressive breast cancer subtype, the HER2 amplified tumor, which could be putatively associated with the loss of immunosurveillance. Conclusion: Our findings suggested an interaction among chronic psychological stress, overweight, and the development of more aggressive breast tumors. |
| Databáze: | MEDLINE |
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