Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel.
| Autor: | Von Atzingen DA; School of Medical Sciences, Universidade do Vale do Sapucaí, Pouso Alegre, MG, BR., Mendonça AR; School of Medical Sciences, UNIVÁS, Pouso Alegre, MG, BR., Mesquita Filho M; School of Medical Sciences, UNIVÁS, Pouso Alegre, MG, BR., Alvarenga VA; School of Medicine, UNIVÁS, BR., Assis VA; School of Medicine, UNIVÁS, BR., Penazzo AE; School of Medicine, UNIVÁS, BR., Muzetti JH; School of Medicine, UNIVÁS, BR., Rezende TS; School of Medicine, UNIVÁS, BR. |
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| Jazyk: | angličtina |
| Zdroj: | Acta cirurgica brasileira [Acta Cir Bras] 2015 Sep; Vol. 30 (9), pp. 586-92. |
| DOI: | 10.1590/S0102-865020150090000001 |
| Abstrakt: | Purpose: To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats. Methods: A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28. Results: On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21. Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28. Conclusion: The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient. |
| Databáze: | MEDLINE |
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