| Autor: |
Bhat R; Department of Pediatrics, University of Illinois, Chicago., John E, Diaz-Blanco J, Ortega R, Fornell L, Vidyasagar D |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of pediatrics [J Pediatr] 1989 Mar; Vol. 114 (3), pp. 443-7. |
| DOI: |
10.1016/s0022-3476(89)80568-2 |
| Abstrakt: |
The effect of artificial surfactant therapy on renal function and the onset of spontaneous diuresis was prospectively evaluated in 19 infants with hyaline membrane disease in a double-blind, controlled study. Twelve infants were in the surfactant group; seven infants received placebo (0.9% saline solution). There was no difference in the time of onset of spontaneous diuresis (as defined by output greater than or equal to 80% of intake). The glomerular filtration rate, determined by endogenous creatinine clearance, was also similar in the surfactant- and placebo-treated infants during the first 3 days of life. The fractional excretion of sodium was significantly higher in the placebo group at 24 hours and 36 hours. Infants in the placebo group had a higher negative sodium balance than those in the surfactant group. Ventilatory status improved significantly soon after surfactant treatment, as evidenced by improvement in the alveolar/arterial oxygen pressure ratio and by a lower mean airway pressure. These data suggest that ventilatory status can be improved without diuresis; the factors that regulate diuresis are multiple and not fully understood. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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