Hypoxia and Inflammation-Induced Disruptions of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers Assessed Using a Novel T1-Based MRI Method.

Autor:	Nathoo N; Department of Radiology, University of Calgary, 3330 Hospital Drive, N.W., Calgary, AB, T2N 4N1, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Jalal H; Department of Radiology, University of Calgary, 3330 Hospital Drive, N.W., Calgary, AB, T2N 4N1, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Natah SS; Department of Physiology, Umm-Alqura University, Makkah, Saudi Arabia., Zhang Q; General Electric, Beijing, China., Wu Y; Department of Radiology, University of Calgary, 3330 Hospital Drive, N.W., Calgary, AB, T2N 4N1, Canada., Dunn JF; Department of Radiology, University of Calgary, 3330 Hospital Drive, N.W., Calgary, AB, T2N 4N1, Canada. dunnj@ucalgary.ca.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. dunnj@ucalgary.ca.; Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada. dunnj@ucalgary.ca.
Jazyk:	angličtina
Zdroj:	Acta neurochirurgica. Supplement [Acta Neurochir Suppl] 2016; Vol. 121, pp. 23-8.
DOI:	10.1007/978-3-319-18497-5_5
Abstrakt:	Subtle blood-brain barrier (BBB) disruption is involved in numerous neurological conditions. This disruption is found diffusely in the brain and requires quantitative methods for assessment. We propose a statistical method to identify individual voxels where the BBB is disrupted using T1-weighted MRI. We used models of severe and focal vs. mild and generalized disruption of the BBB to show proof of principle with the cold injury model, hypoxia, and a model of inflammation using low- and high-dose lipopolysaccharide (LPS) treatment. Using voxel-based analysis, we found that mild hypoxia resulted in diffuse disruption of the BBB, whereas more severe hypoxia and high-dose LPS treatment resulted in prominent leakage, particularly in the periventricular area, suggestive of blood-cerebrospinal fluid (CSF) barrier disruption. Our data suggest that the periventricular area may be compromised first in conditions of inflammation and hypoxia. Voxel-based analysis could be used in future studies assessing subtle blood-CSF or BBB disruption.
Databáze:	MEDLINE
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