Amoeboid movement in protozoan pathogens.

Autor: Dufour AC; Institut Pasteur, Bioimage Analysis Unit, Department of Cell Biology & Infection, Paris, France; CNRS UMR 3691 'Pathological and Physiological Cell Dynamics', Paris, France. Electronic address: adufour@pasteur.fr., Olivo-Marin JC; Institut Pasteur, Bioimage Analysis Unit, Department of Cell Biology & Infection, Paris, France; CNRS UMR 3691 'Pathological and Physiological Cell Dynamics', Paris, France. Electronic address: jcolivo@pasteur.fr., Guillen N; Institut Pasteur, Cell Biology of Parasitism Unit, Department of Cell Biology & Infection, Paris, France; INSERM U786, Paris, France. Electronic address: nguillen@pasteur.fr.
Jazyk: angličtina
Zdroj: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2015 Oct; Vol. 46, pp. 128-34. Date of Electronic Publication: 2015 Oct 13.
DOI: 10.1016/j.semcdb.2015.10.010
Abstrakt: Entamoeba histolytica, the causative agent of amoebiasis, is a protozoan parasite characterised by its amoeboid motility, which is essential to its survival and invasion of the human host. Elucidating the molecular mechanisms leading to invasion of human tissues by E. histolytica requires a quantitative understanding of how its cytoskeleton deforms and tailors its mode of migration to the local microenvironment. Here we review the wide range of methods available to extract biophysical information from amoeboid cells, from interventional techniques to computational modelling approaches, and discuss how recent developments in bioimaging and bioimage informatics can complement our understanding of cellular morphodynamics at the intracellular level.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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