Pulmonary artery enlargement in schistosomiasis associated pulmonary arterial hypertension.

Autor: Hoette S; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. susana.hoette@gmail.com., Figueiredo C; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. claudia.figueiredo@fleury.com.br., Dias B; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. bradias2011@gmail.com., Alves JL Jr; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. jleonidasajr@gmail.com., Gavilanes F; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. Franciscagavilanesmd@gmail.com., Prada LF; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. luisfelipe.prada@gmail.com., Jasinowodolinski D; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. danyjasino@gmail.com., Morinaga LT; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. ltkmorinaga@gmail.com., Jardim C; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. carlosvpjardim@me.com., Fernandes CJ; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. cjcfernandes@gmail.com., Souza R; Pulmonary Department - Heart Institute, University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44, Sao Paulo, 05403-000, Brazil. souza.rogerio@me.com.
Jazyk: angličtina
Zdroj: BMC pulmonary medicine [BMC Pulm Med] 2015 Oct 12; Vol. 15, pp. 118. Date of Electronic Publication: 2015 Oct 12.
DOI: 10.1186/s12890-015-0115-y
Abstrakt: Background: Schistosomiasis associated pulmonary arterial hypertension (Sch-PAH) might represent the most prevalent form of PAH worldwide. In Sch-PAH, the presence of aneurismal dilation of the pulmonary artery has been described, although it is still a matter of debate whether on average the pulmonary artery is more enlarged in Sc-PAH than IPAH.
Methods: We retrospectively evaluated patients with IPAH (n = 25) and Sch-PAH (n = 22) who underwent computed tomography pulmonary angiogram and right heart catheterization.
Results: Sch-PAH patients were older and presented less severe hemodynamic profiles. Main pulmonary artery diameter (MPAD) was greater in Sch-PAH than IPAH (4.5 ± 1.8 vs 3.7 ± 1.1 cm, p = 0.018). For the same level of mean pulmonary artery pressure, the MPAD in Sch-PAH was 0.89 cm larger than in IPAH (Covariance model p = 0.02).
Conclusion: This study demonstrated that pulmonary artery enlargement is more pronounced in Sch-PAH than IPAH, independently of mean pulmonary artery pressure level, suggesting that this is more likely a feature of Sch-PAH.
Databáze: MEDLINE
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