Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique.

Autor:	van Onna M; Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands., Ten Cate DF; Department of Rheumatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Tsoi KL; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Meier AJ; Department of Rheumatology, Regional Rheumatology Center, Eindhoven, The Netherlands., Jacobs JW; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Westgeest AA; Department of Rheumatology, Regional Rheumatology Center, Eindhoven, The Netherlands., Meijer PB; Hemics, Eindhoven, The Netherlands., van Beek MC; Hemics, Eindhoven, The Netherlands., Rensen WH; Hemics, Eindhoven, The Netherlands., Bijlsma JW; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Jazyk:	angličtina
Zdroj:	Annals of the rheumatic diseases [Ann Rheum Dis] 2016 Mar; Vol. 75 (3), pp. 511-8. Date of Electronic Publication: 2015 Oct 09.
DOI:	10.1136/annrheumdis-2015-207315
Abstrakt:	Objectives: In rheumatoid arthritis (RA), treat-to-target strategies require instruments for valid detection of joint inflammation. Therefore, imaging modalities are increasingly used in clinical practice. Optical spectral transmission (OST) measurements are non-invasive and fast and may therefore have benefits over existing imaging modalities. We tested whether OST could measure disease activity validly in patients with RA. Methods: In 59 patients with RA and 10 patients with arthralgia, OST, joint counts, Disease Activity Score (DAS) 28 and ultrasonography (US) were performed. Additionally, MRI was performed in patients with DAS28<2.6. We developed and validated within the same cohort an algorithm for detection of joint inflammation by OST with US as reference. Results: At the joint level, OST and US performed similarly inproximal interphalangeal-joints (area under the receiver-operating curve (AUC) of 0.79, p<0.0001) andmetacarpophalangeal joints (AUC 0.78, p<0.0001). Performance was less similar in wrists (AUC 0.62, p=0.006). On the patient level, OST correlated moderately with clinical examination (DAS28 r=0.42, p=0.001), and US scores (r=0.64, p<0.0001). Furthermore, in patients with subclinical and low disease activity, there was a correlation between OST and MRI synovitis score (RAMRIS (Rheumatoid Arthritis MRI Scoring) synovitis), r=0.52, p=0.005. Conclusions: In this pilot study, OST performed moderately in the detection of joint inflammation in patients with RA. Further studies are needed to determine the diagnostic performance in a new cohort of patients with RA. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
Databáze:	MEDLINE
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