| Autor: |
Toneatto J; Laboratory of Nuclear Architecture; Instituto de Biología y Medicina Experimental - CONICET ; Buenos Aires, Argentina., Charó NL; Laboratory of Nuclear Architecture; Instituto de Biología y Medicina Experimental - CONICET ; Buenos Aires, Argentina., Galigniana NM; Laboratory of Nuclear Architecture; Instituto de Biología y Medicina Experimental - CONICET ; Buenos Aires, Argentina., Piwien-Pilipuk G; Laboratory of Nuclear Architecture; Instituto de Biología y Medicina Experimental - CONICET ; Buenos Aires, Argentina. |
| Jazyk: |
angličtina |
| Zdroj: |
Adipocyte [Adipocyte] 2015 May 13; Vol. 4 (4), pp. 239-47. Date of Electronic Publication: 2015 May 13 (Print Publication: 2015). |
| DOI: |
10.1080/21623945.2015.1049401 |
| Abstrakt: |
Adipose tissue plays a central role in the control of energy balance as well as in the maintenance of metabolic homeostasis. It was not until recently that the first evidences of the role of heat shock protein (Hsp) 90 and high molecular weight immunophilin FKBP51 have been described in the process of adipocyte differentiation. Recent reports describe their role in the regulation of PPARγ, a key transcription factor in the control of adipogenesis and the maintenance of the adipocyte phenotype. In addition, novel roles have been uncovered for FKBP51 in the organization of the architecture of the nucleus through its participation in the reorganization of the nuclear lamina. Therefore, the aim of this review is to integrate and discuss the recent advances in the field, with special emphasis on the roles of Hsp90 and FKBP51 in the process of adipocyte differentiation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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