| Autor: |
Deshpande R; Interactive Research School for Health Affairs (IRSHA), BharatiVidyapeeth University, Katraj-Dhankawadi, Pune-Satara Road, Pune, 411043, Maharashtra, India., Mansara P; Interactive Research School for Health Affairs (IRSHA), BharatiVidyapeeth University, Katraj-Dhankawadi, Pune-Satara Road, Pune, 411043, Maharashtra, India., Kaul-Ghanekar R; Interactive Research School for Health Affairs (IRSHA), BharatiVidyapeeth University, Katraj-Dhankawadi, Pune-Satara Road, Pune, 411043, Maharashtra, India. ruchika.kaulghanekar@gmail.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2016 Mar; Vol. 37 (3), pp. 3295-305. Date of Electronic Publication: 2015 Oct 06. |
| DOI: |
10.1007/s13277-015-4170-z |
| Abstrakt: |
Cervical cancer represents the largest cause of mortality in women worldwide. In our previous report, we have shown how alpha-linolenic acid (ALA), an omega-3 fatty acid, regulated the growth of cervical cancer cells. The present study aimed to explore mechanistic details for the anticancer activity of ALA in cervical cancer cell lines, SiHa and HeLa. ALA significantly modulated the growth kinetics of the cells and reduced cell migration with concomitant decrease in the expression of VEGF, MMP-2, and MMP-9 proteins. Besides this, ALA significantly decreased the expression of phosphorylated p38, pERK1/2, c-JUN, NFκB, and COX2, proteins. Most importantly, ALA reduced the expression of HPV onco-proteins E6 and E7, resulting into restoration of expression of tumor suppressor proteins, p53 and Rb. These results suggested that ALA could be explored for its therapeutic potential in cervical cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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