Dynamics of immune parameters during the treatment of active tuberculosis showing negative interferon gamma response at the time of diagnosis.

Autor:	Matsushita I; Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis - Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-8533, Japan., Hang NT; NCGM-BMH Medical Collaboration Center, Hanoi, Vietnam., Hong le T; Department of Biochemistry, Hematology and Blood Transfusion, Hanoi Lung Hospital, Hanoi, Vietnam., Tam do B; Department of Biochemistry, Hematology and Blood Transfusion, Hanoi Lung Hospital, Hanoi, Vietnam., Lien LT; Hanoi Department of Health, Hanoi, Vietnam., Thuong PH; Hanoi Lung Hospital, Hanoi, Vietnam., Cuong VC; Hanoi Department of Health, Hanoi, Vietnam., Hijikata M; Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis - Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-8533, Japan; National Center for Global Health and Medicine, Tokyo, Japan., Kobayashi N; NHO Tokyo National Hospital, Tokyo, Japan., Sakurada S; Bureau of International Medical Cooperation, National Center for Global Health and Medicine, Tokyo, Japan., Higuchi K; Research Institute of Immune Diagnosis, Tokyo, Japan., Harada N; Research Institute of Immune Diagnosis, Tokyo, Japan., Keicho N; Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis - Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-8533, Japan; National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: nkeicho-tky@umin.ac.jp.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2015 Nov; Vol. 40, pp. 39-44. Date of Electronic Publication: 2015 Oct 09.
DOI:	10.1016/j.ijid.2015.09.021
Abstrakt:	Objectives: In the performance of interferon gamma release assays (IGRA) for the diagnosis of tuberculosis (TB) infection, false-negative results are a major obstacle. In active TB patients, treatment-dependent changes of the negative test results remain unknown. Methods: The treatment course of 19 smear-positive/culture-confirmed TB patients who had IGRA-negative results by QuantiFERON-TB in-tube (QFT-IT) method at the time of diagnosis (month 0) in a previous study, were monitored in the present study. Blood was further collected at months 2 and 7, and the concentrations of 27 immune molecules were measured in the plasma supernatants remaining after performing the IGRA, using a suspension array system. Results: After initiating treatment, eight of the 19 QFT-IT-negative patients showed positive conversion, whereas the remaining 11 (58%) did not; the interferon gamma (IFN-γ) response was restored to levels higher than 1 IU/ml in only three of the eight patients with positive conversion. Plasma concentrations of interleukin 1 receptor antagonist, interleukin 2, and interferon gamma-induced protein 10 remained low after Mycobacterium tuberculosis-specific antigen stimulation at months 2 and 7 in the continuously QFT-IT-negative group, whereas the parameters were elevated only in the transiently QFT-IT-negative group. Conclusions: It was demonstrated that a majority of active TB patients showing negative IGRA results did not regain sufficient levels of immune responsiveness despite successful treatment. (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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