Upregulation of integrin expression on monocytes in multiple sclerosis patients treated with natalizumab.

Autor: Dallari S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Franciotta D; Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy., Carluccio S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Signorini L; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Gastaldi M; Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy., Colombo E; Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy., Bergamaschi R; Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy., Elia F; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Villani S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Ferrante P; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy; Fondazione Ettore Sansavini, Health Science Foundation, Lugo, Italy., Delbue S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy. Electronic address: serena.delbue@unimi.it.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2015 Oct 15; Vol. 287, pp. 76-9. Date of Electronic Publication: 2015 Aug 14.
DOI: 10.1016/j.jneuroim.2015.08.010
Abstrakt: Natalizumab is a humanized monoclonal antibody against the α4 subunit of VLA-4 integrin that is used to treat conditions such as multiple sclerosis (MS). Although its effects on lymphocytes have been widely described, little is known about its effects on monocytes. Here we described the effects of natalizumab treatment on peripheral blood monocytes from a small cohort of MS patients in terms of relative frequencies and surface integrin (CD49d and CD18) expression. We showed that natalizumab treatment altered the surface integrin expression on monocyte subsets in the peripheral compartment, suggesting a role for them as mediators of natalizumab effects.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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