Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial.

Autor:	Neville IS; Division of Neurosurgery, Hospital das Clínicas, University of São Paulo, Rua Dr Eneas Aguiar, 255 / 4079; 05403-010, São Paulo, SP, Brazil. iurineville@yahoo.com.br.; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. iurineville@yahoo.com.br.; Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. iurineville@yahoo.com.br., Hayashi CY; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. cintya.hayashi@yahoo.com.br.; Nursing School, University of São Paulo, São Paulo, Brazil. cintya.hayashi@yahoo.com.br., El Hajj SA; Division of Neuropsychology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. simoneaassis@gmail.com., Zaninotto AL; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. ana.zaninotto@yahoo.com.br.; Division of Neuropsychology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. ana.zaninotto@yahoo.com.br., Sabino JP; Division of Neuropsychology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. jjjnperez@hotmail.com., Sousa LM Jr; Division of Neurosurgery, Hospital das Clínicas, University of São Paulo, Rua Dr Eneas Aguiar, 255 / 4079; 05403-010, São Paulo, SP, Brazil. leonardomoura.jr@hotmail.com.; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. leonardomoura.jr@hotmail.com.; Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. leonardomoura.jr@hotmail.com., Nagumo MM; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. marcianagumo@gmail.com., Brunoni AR; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. brunowsky@gmail.com.; Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. brunowsky@gmail.com., Shieh BD; Division of Neuropsychology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. barbara@shieh.com.br., Amorim RL; Division of Neurosurgery, Hospital das Clínicas, University of São Paulo, Rua Dr Eneas Aguiar, 255 / 4079; 05403-010, São Paulo, SP, Brazil. amorim.robson@gmail.com.; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. amorim.robson@gmail.com.; Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. amorim.robson@gmail.com., Teixeira MJ; Division of Neurosurgery, Hospital das Clínicas, University of São Paulo, Rua Dr Eneas Aguiar, 255 / 4079; 05403-010, São Paulo, SP, Brazil. manoeljacobsen@gmail.com.; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. manoeljacobsen@gmail.com.; Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. manoeljacobsen@gmail.com., Paiva WS; Division of Neurosurgery, Hospital das Clínicas, University of São Paulo, Rua Dr Eneas Aguiar, 255 / 4079; 05403-010, São Paulo, SP, Brazil. wellingsonpaiva@yahoo.com.br.; Service of Interdisciplinary Neuromodulation, University of São Paulo, São Paulo, Brazil. wellingsonpaiva@yahoo.com.br.; Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil. wellingsonpaiva@yahoo.com.br.
Jazyk:	angličtina
Zdroj:	Trials [Trials] 2015 Oct 05; Vol. 16, pp. 440. Date of Electronic Publication: 2015 Oct 05.
DOI:	10.1186/s13063-015-0944-2
Abstrakt:	Background: Repetitive Transcranial Magnetic Stimulation (rTMS) has been proposed as a new tool in neurological rehabilitation of victims of traumatic brain injury (TBI). However, its usefulness to treat this condition has never been tested rigorously. The primary goal is to conduct a study protocol to determine whether rTMS used to cognitive rehabilitation of victims of TBI with diffuse axonal injury (DAI) is a safe instrument and if it enhances cognitive function recovery. Methods: Double-blind randomized controlled trial of patients with diffuse axonal injury. Thirty-six patients will be randomized to either an active coil group or sham group in a 1:1 ratio. rTMS protocol: 10 sessions of high-frequency rTMS (10 Hz) over the left dorsolateral prefrontal cortex (DLPFC). Cortical Excitability measures will be obtained. Neuropsychological evaluations will be performed 1 week before, 1 week and 3 months after rTMS. There are 2 study hypotheses: (1) rTMS over the left DLPFC in patients with DAI will improve cognitive function and (2) whether rTMS is safe in TBI patients. Discussion: This study evaluates the immediate and delayed effects of rTMS over the DLPFC on the cognitive domain of patients with DAI following TBI. rTMS has shown good results in treating major depression and may be promising for patients with TBI. As such, the results of this study can greatly modify the cognitive rehabilitation strategies. Trial Registration: This trial was registered in clinicaltrials.gov ( NCT02167971 ) on 17 June 2014.
Databáze:	MEDLINE
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