The role of bariatric surgery in the management of nonalcoholic fatty liver disease and metabolic syndrome.

Autor: Aguilar-Olivos NE; Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico., Almeda-Valdes P; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Aguilar-Salinas CA; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Uribe M; Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico., Méndez-Sánchez N; Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico. Electronic address: nmendez@medicasur.org.mx.
Jazyk: angličtina
Zdroj: Metabolism: clinical and experimental [Metabolism] 2016 Aug; Vol. 65 (8), pp. 1196-207. Date of Electronic Publication: 2015 Sep 11.
DOI: 10.1016/j.metabol.2015.09.004
Abstrakt: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD is strongly associated with obesity and metabolic syndrome (MetS). Current treatment of NAFLD is based on weight reduction. Bariatric surgery is the most effective treatment for morbid obesity and its associated metabolic comorbidities. There is evidence indicating that bariatric surgery improves histological and biochemical parameters of NAFLD, but currently is not considered a treatment option for NAFLD. The aim of this work is to review the evidence for the effects of bariatric surgery on NAFLD and the MetS. We found that insulin resistance, alterations in glucose metabolism, hypertension, plasma lipids, transaminases, liver steatosis, steatohepatitis and fibrosis improve after bariatric surgery. Weight loss and improvement of NAFLD are greater after RYGB than after other interventions. These findings were obtained from retrospective or cohort studies. There are no studies designed to evaluate liver-specific mortality, liver transplantation, or quality of life. Patients with indications for bariatric surgery will benefit from the improvements in the MetS and NAFLD.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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