Survival of rat cerebrocortical neurons after rickettsial infection.

Autor: Bohácsová M; Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Filipčík P; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Opattová A; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Valáriková J; Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Quevedo Diaz M; Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Škultéty L; Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Novák M; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Sekeyová Z; Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address: viruseke@savba.sk.
Jazyk: angličtina
Zdroj: Microbes and infection [Microbes Infect] 2015 Nov-Dec; Vol. 17 (11-12), pp. 845-9. Date of Electronic Publication: 2015 Oct 09.
DOI: 10.1016/j.micinf.2015.09.024
Abstrakt: Neuroinvasive microorganisms are suspected to play an important role in the etiopathogenesis of neurological diseases. However, direct evidence for the pathogenic function is still missing. The main aim of this study was to investigate biochemical and morphological changes that may occur as a result of an in vitro infection of rat cerebrocortical neurons by selected members of the genus Rickettsia. Our results showed that survival of the neurons is significantly reduced after the infection. Intracellular level of ATP is gradually decreased and inversely correlates with the load of rickettsiae. Immunofluorescence revealed that rickettsiae can enter the neurons and are localized in perinuclear space and also in neuronal processes. Data obtained in this study correspond to the idea of possible involvement of rickettsiae in the etiopathogenesis of various neuropathies.
(Copyright © 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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