The Hruska postulate of Crohn's disease.
| Autor: | Monif GR; Infectious Diseases Incorporated, Bellevue, NE, United States; University of Florida, College of Veterinary Medicine, Gainesville, FL, United States. Electronic address: gmonif@AOL.com. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Medical hypotheses [Med Hypotheses] 2015 Dec; Vol. 85 (6), pp. 878-81. Date of Electronic Publication: 2015 Sep 30. |
| DOI: | 10.1016/j.mehy.2015.09.019 |
| Abstrakt: | Crohn's disease is due to the loss of immunological tolerance within the gastrointestinal tract to the antigenic array of Mycobacterium avium subspecies paratuberculosis (MAP) and closely related polymorphic variants. The loss of immune tolerance results in an effector cytokine responsive upon re-exposure to MAP. For immune tolerance to MAP to be induced, infection must occur when acquired immunity is markedly underdeveloped. (Copyright © 2015 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect