Serum Levels of MDC and MMP-9 and the Relationship Between Serum Levels and Disease Activity in the Patients with Systemic Lupus Erythematosus.

Autor:	Liu Y; Yang Liu, PhD Department of Rheumatology, the First Affiliated Hospital, Inner Mongolia Medical University, China., Tie N; Ning Tie, M.S Department of Rheumatology, the First Affiliated Hospital, Inner Mongolia Medical University, China., Bai L; Li-Jie Bai, M.S Department of Rheumatology, the First Affiliated Hospital, Inner Mongolia Medical University, China.
Jazyk:	angličtina
Zdroj:	Pakistan journal of medical sciences [Pak J Med Sci] 2015 Jul-Aug; Vol. 31 (4), pp. 803-6.
DOI:	10.12669/pjms.314.7325
Abstrakt:	Background and Objective: Systemic lupus erythematosus (SLE) is a complicated autoimmune disease. Although its pathogenesis is not clear, cytokine may be involved in it. So we investigated serum levels of macrophage-derived chemokine (MDC), and matrix metalloproteinase-9 (MMP-9), and to determine the relationship between serum levels and the disease activity of SLE. Methods: Serum levels of MDC and MMP-9 were measured by enzyme-linked immuno sorbent assay (ELISA). Results: Significantly decreased serum levels of MDC and MMP-9 were found in SLE as compared to those in controls (P<0.001 P<0.001), but serum levels of MDC and MMP-9 increased after treatment (P<0.001 P<0.05). Serum levels of MDC and MMP-9 were lower in patients with active disease than those with inactive disease (P<0.001 P<0.05). Significantly decreased serum levels of MDC and MMP-9 were found in patients with renal damage than those without the damage (P<0.001 P<0.05). Serum level of MDC was lower in patients with arthritis than those without the damage (P<0.001), but serum level of MMP-9 has no significant difference in two groups (P>0.05). Conclusion: The present data suggest that MDC and MMP-9 may be involved in the pathogenesis of SLE, and serum levels of MDC and MMP-9 could be markers of monitoring disease activity, renal damage, disease progression and improvement in SLE.
Databáze:	MEDLINE
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