Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly(N-vinylcaprolactam).

Autor: Fernández-Quiroz D; CIAD - Guaymas, Carret. al Varadero Nacional km 6.6, Guaymas, Sonora 85480, Mexico., González-Gómez Á; ICTP-CSIC c/ Juan de la Cierva 3, 28006 Madrid and CIBER, Health Institute Carlos III, C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain., Lizardi-Mendoza J; CIAD - Hermosillo, Carret. a la Victoria km 0.6, Hermosillo, Sonora 83304, Mexico., Vázquez-Lasa B; ICTP-CSIC c/ Juan de la Cierva 3, 28006 Madrid and CIBER, Health Institute Carlos III, C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain., Goycoolea FM; CIAD - Hermosillo, Carret. a la Victoria km 0.6, Hermosillo, Sonora 83304, Mexico; Westfälische Wilhelms Universität Münster, IBBP, Schlossgarten 3, D-48149 Münster, Germany., San Román J; ICTP-CSIC c/ Juan de la Cierva 3, 28006 Madrid and CIBER, Health Institute Carlos III, C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain., Argüelles-Monal WM; CIAD - Guaymas, Carret. al Varadero Nacional km 6.6, Guaymas, Sonora 85480, Mexico. Electronic address: waldo@ciad.mx.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2015 Dec 10; Vol. 134, pp. 92-101. Date of Electronic Publication: 2015 Jul 26.
DOI: 10.1016/j.carbpol.2015.07.069
Abstrakt: A series of thermoresponsive copolymers based on chitosan-g-poly(N-vinylcaprolactam) were synthesized by amidation reaction using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride as coupling reagent. The effect of molecular architecture on the thermoresponsive properties of the graft copolymers solutions was studied by varying the chain length of the grafted poly(N-vinylcaprolactam), PVCL, (in the range from 4 to 26 kDa) and the spacing between grafted chains onto the chitosan backbone. The most interesting characteristic of these copolymers is their solubility in water at temperatures below their lower critical solution temperature (LCST). These solutions presented a LCST between 36 and 44 °C, which decreases with the spacing and length of grafted PVCL chains onto the chitosan backbone, in contrast with the limited decrease of the LCST of PVCL above a critical M¯n value around 18 kDa. This behavior offers tangible possibilities for the preparation and application of sensitive bioactive formulations and "smart" drug delivery systems.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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