| Autor: |
Lucaciu LA; 2 Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania., Dumitrascu DL; 2 Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania. |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of gastroenterology [Ann Gastroenterol] 2015 Oct-Dec; Vol. 28 (4), pp. 440-7. |
| Abstrakt: |
Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects. We aimed to review the available data on the depression and suicide in CHC patients receiving or not antiviral therapy based on interferon treatment. A PubMed search was performed, identifying relevant papers published between 1991 and January 2015 concerning major depressive disorders and suicidal risk in patients under interferon. A total of 21 relevant papers were retrieved. Prospective studies reported depression as the most common side effect of interferon, with an incidence peak between weeks 8 and 12 of therapy. Suicide risk was analyzed in 7 of the reviewed articles, and case reports of attempted suicide were discussed. Moreover, studies have shown that pretreatment with serotonin reuptake inhibitors is a good strategy for the prevention of interferon-induced depression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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