Association of the COL1A1 gene polymorphisms in Mexican postmenopausal women with fracture or with low bone mineral density at the hip.

Autor: Falcón-Ramírez E; Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico., Hidalgo-Bravo A; Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico., Barredo-Prieto BA; Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico., Pineda-Gómez E; Servicio de Traumatología, Instituto Nacional de Rehabilitación, Mexico City, Mexico., Valdés-Flores M; Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico. efalcon2005@gmail.com.
Jazyk: angličtina
Zdroj: Aging clinical and experimental research [Aging Clin Exp Res] 2016 Jun; Vol. 28 (3), pp. 567-71. Date of Electronic Publication: 2015 Sep 30.
DOI: 10.1007/s40520-015-0449-6
Abstrakt: Background and Aims: Osteoporosis leads to high fracture risk and evidence suggests that genetic factors play an important role in this disease. The aim was to evaluate the association of two polymorphisms (-1997G/T, +1245G/T) in the collagen type1 alpha 1 gene (COL1A1) with fracture or with low bone mineral density (BMD) at the hip in postmenopausal Mexican women.
Methods: BMD was determined by bone densitometry and the risk factors were collected with a questionnaire. Genotyping was performed by real-time PCR.
Results: The polymorphisms were in Hardy-Weinberg equilibrium. The -1997G/+1245T haplotype showed, after adjustment for confounders, a fourfold increased risk of hip fracture [OR 4.32; p = 0.041 (95 % CI 1.07-17.43)]; while in the women with low BMD at the hip, the risk was increased threefold [OR 3.36; p = 0.022 (95 % CI 1.20-9.40)].
Conclusions: The results support the association of COL1A1 gene polymorphisms with fracture and with low BMD at the hip in Mexican population.
Databáze: MEDLINE
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