Effect of obesity on telomere length: Systematic review and meta-analysis.

Autor: Mundstock E; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil., Sarria EE; School of Medicine, Department of Biology and Pharmacy, Universidade De Santa Cruz Do Sul (UNISC), Santa Cruz, Brazil., Zatti H; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil., Mattos Louzada F; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil., Kich Grun L; Departmento De Bioquímica, ICBS, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil., Herbert Jones M; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil., Guma FT; Departmento De Bioquímica, ICBS, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil., Mazzola In Memoriam J; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil., Epifanio M; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil., Stein RT; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil., Barbé-Tuana FM; Departmento De Bioquímica, ICBS, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil., Mattiello R; Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2015 Nov; Vol. 23 (11), pp. 2165-74. Date of Electronic Publication: 2015 Sep 26.
DOI: 10.1002/oby.21183
Abstrakt: Objective: The main objective of this systematic review is to assess the effects of obesity on telomere length.
Methods: The following databases were searched: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), LILACS, SPORTdiscus, and Web of Science from inception to August 2014. The search was performed using the following combinations of terms: telomere AND "overweight" OR "obesity" OR "adiposity," without language restriction.
Results: Sixty-three original studies were included in this systematic review, comprising 119,439 subjects. Thirty-nine studies showed either weak or moderate correlation between obesity and telomere length; however, they showed an important heterogeneity.
Conclusions: There is a tendency toward demonstrating negative correlation between obesity and telomere length. The selected studies showed weak to moderate correlation for the main search, and there was an important heterogeneity. For this reason, the causal relationship of obesity and telomere length remains open. Additional controlled longitudinal studies are needed to investigate this issue.
(© 2015 The Obesity Society.)
Databáze: MEDLINE
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