Influence of Polymorphism (-G308A) TNF-α on the Periportal Fibrosis Regression of Schistosomiasis After Specific Treatment.

Autor:	Oliveira JB; 1 Gastroenterologia, Hospital das Clínicas , Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil ., Silva PC; 2 Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão, Pernambuco, Brazil .; 3 Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz , Universidade de Pernambuco, Recife, Pernambuco, Brazil ., Vasconcelos LM; 2 Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão, Pernambuco, Brazil ., Gomes AV; 3 Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz , Universidade de Pernambuco, Recife, Pernambuco, Brazil .; 4 Instituto de Ciências Biológicas, Universidade de Pernambuco , Recife, Pernambuco, Brazil ., Coêlho MR; 5 Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami (LIKA), Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil .; 6 Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil ., Cahu GG; 5 Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami (LIKA), Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil ., Muniz MT; 3 Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz , Universidade de Pernambuco, Recife, Pernambuco, Brazil .; 4 Instituto de Ciências Biológicas, Universidade de Pernambuco , Recife, Pernambuco, Brazil .; 7 Faculdade de Ciências Médicas, Universidade de Pernambuco , Recife, Pernambuco, Brazil ., Domingues AL; 8 Departamento de Medicina Clínica, Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil .
Jazyk:	angličtina
Zdroj:	Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2015 Nov; Vol. 19 (11), pp. 598-603. Date of Electronic Publication: 2015 Sep 25.
DOI:	10.1089/gtmb.2015.0091
Abstrakt:	Aims: Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine and important mediator of severity for periportal fibrosis (PPF). We hypothesized that the (-G380A) polymorphism in the TNF-α gene is associated with regression of PPF after treatment for schistosomiasis mansoni. Methods: This is a retrospective cohort study, involving 124 Brazilian patients infected with Schistosoma mansoni, who were followed for 2 years after treatment to estimate the likelihood of PPF regression. Sociodemographic and clinical factors were also identified, with emphasis on specific treatment. Results: No statistical difference was observed between sociodemographic and clinical factors among the exposed groups. Genotypes (-308) GA/AA were positively associated with the degree of PFF regression (relative risk [RR] = 0.52; ρ = 0.025), as well as in the image pattern of PPF (RR = 0.56; ρ = 0.048), when compared with the genotype (-308) GG. There was no statistical difference in TNF-α serum levels between the exposed groups. Conclusions: These results suggest that the (-G308A) polymorphism of the TNF-α gene may be one of the factors that prevents the regression of the degree and pattern of PPF in the Brazilian population, and thus it may potentially be a predictive factor of PPF intensity in schistosomiasis.
Databáze:	MEDLINE
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