Simulation of the charge migration in DNA under irradiation with heavy ions.
| Autor: | Belov OV; Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia., Boyda DL; Far Eastern Federal University, 8 Sukhanov Street, 690950 Vladivostok, Russia., Plante I; Wyle Science, Technology and Engineering, 1300 Hercules Ave, Houston, Texas 77058, USA., Shirmovsky SE; Far Eastern Federal University, 8 Sukhanov Street, 690950 Vladivostok, Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Bio-medical materials and engineering [Biomed Mater Eng] 2015; Vol. 26 Suppl 1, pp. S1937-44. |
| DOI: | 10.3233/BME-151496 |
| Abstrakt: | A computer model to simulate the processes of charge injection and migration through DNA after irradiation by a heavy charged particle was developed. The most probable sites of charge injection were obtained by merging spatial models of short DNA sequence and a single 1 GeV/u iron particle track simulated by the code RITRACKS (Relativistic Ion Tracks). Charge migration was simulated by using a quantum-classical nonlinear model of the DNA-charge system. It was found that charge migration depends on the environmental conditions. The oxidative damage in DNA occurring during hole migration was simulated concurrently, which allowed the determination of probable locations of radiation-induced DNA lesions. |
| Databáze: | MEDLINE |
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