Clinical and immunological aspects and outcome of a Brazilian cohort of 414 patients with systemic lupus erythematosus (SLE): comparison between childhood-onset, adult-onset, and late-onset SLE.

Autor: das Chagas Medeiros MM; Federal University of Ceará, Fortaleza, Brazil mmcmedeiros@hotmail.com., Bezerra MC; Federal University of Ceará, Fortaleza, Brazil., Braga FN; Federal University of Ceará, Fortaleza, Brazil., da Justa Feijão MR; Federal University of Ceará, Fortaleza, Brazil., Gois AC; Federal University of Ceará, Fortaleza, Brazil., Rebouças VC; Federal University of Ceará, Fortaleza, Brazil., de Carvalho TM; Federal University of Ceará, Fortaleza, Brazil., Carvalho LN; Federal University of Ceará, Fortaleza, Brazil., Ribeiro ÁM; Federal University of Ceará, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2016 Apr; Vol. 25 (4), pp. 355-63. Date of Electronic Publication: 2015 Sep 23.
DOI: 10.1177/0961203315606983
Abstrakt: The clinical expression of systemic lupus erythematosus (SLE) is influenced by genetic and environmental factors and therefore varies between ethnicities. Information on the epidemiology of SLE in Brazil is scarce and practically limited to studies conducted in socioeconomically developed regions (South and Southeast). The objective of this study was to describe the clinical and immunological aspects and outcome of a cohort of patients with SLE treated at a university hospital in northeastern Brazil and compare patterns related to age at onset: childhood (cSLE), adult (aSLE), and late (lSLE). A random sample of 414 records (women: 93.5%) were reviewed. The mean age at SLE onset and the mean disease duration were 28.9 ± 10.9 years and 10.2 ± 6.6 years, respectively. Most patients had aSLE (n = 338; 81.6%), followed by cSLE (n = 60; 14.5%) and lSLE (n = 16; 3.9%). The female/male ratio was 6.5:1 in cSLE and 16.8:1 in aSLE; in lSLE, all patients were female (p = 0.05). During follow-up, the cSLE group presented higher rates of nephritis (70% vs. 52.9% vs. 12.5%; p = 0.0001) and leuko/lymphopenia (61.7% vs. 43.8% vs. 56.2%; p = 0.02). No significant differences were found for anti-dsDNA, anti-Sm, and antiphospholipid antibodies. Treatment with immunosuppressants was significantly more common, and higher doses of prednisone were used, in cSLE. The prevalence of cardiovascular diseases were more frequent in lSLE (p = 0.03). No significant differences were found between the three groups with regard to mean damage accrual (SDI), remission, and mortality. Although cSLE presented higher rates of nephritis and leuko/lymphopenia, more frequent use of immunosuppressants and higher prednisone doses than aSLE and lSLE, the three groups did not differ significantly with regard to damage accrual, remission, and mortality.
(© The Author(s) 2015.)
Databáze: MEDLINE
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