Serum and Aqueous Concentrations of Inflammatory Markers in Diabetic Macular Edema.

Autor: Kocabora MS; a Ophthalmology Department, Faculty of Medicine , Medipol University , Istanbul , Turkey .; b Ophthalmology Department , Vakif Gureba Hospital , Istanbul , Turkey , and., Telli ME; b Ophthalmology Department , Vakif Gureba Hospital , Istanbul , Turkey , and., Fazil K; b Ophthalmology Department , Vakif Gureba Hospital , Istanbul , Turkey , and., Erdur SK; a Ophthalmology Department, Faculty of Medicine , Medipol University , Istanbul , Turkey ., Ozsutcu M; a Ophthalmology Department, Faculty of Medicine , Medipol University , Istanbul , Turkey .; b Ophthalmology Department , Vakif Gureba Hospital , Istanbul , Turkey , and., Cekic O; b Ophthalmology Department , Vakif Gureba Hospital , Istanbul , Turkey , and.; c Ophthalmology Department, Faculty of Medicine , Marmara University , Istanbul , Turkey., Ozbilen KT; b Ophthalmology Department , Vakif Gureba Hospital , Istanbul , Turkey , and.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2016 Oct; Vol. 24 (5), pp. 549-54. Date of Electronic Publication: 2015 Sep 23.
DOI: 10.3109/09273948.2015.1034804
Abstrakt: Purpose: To investigate the relationship between the serum and aqueous levels of inflammatory markers and diabetic macular edema (DME).
Methods: The study included four patient groups: the healthy control group (n = 23 eyes); the diabetic control group (n = 22 eyes); the groups with and without DME (n = 20 eyes and n = 22 eyes, respectively). The patients were evaluated based on their serum levels of HbA1c, C-reactive protein (CRP) and serum and aqueous levels of tumor necrosis factor-alpha (TNF-α).
Results: Statistically significant differences were present for the serum CRP levels and for the aqueous TNF-α levels between the healthy control group and the group with DME (p = 0.004 and p = 0.03, respectively); for the serum TNF-α levels between the healthy control group and the groups without and with DME (p = 0.009 and p = 0.001, respectively).
Conclusions: Increased serum levels of CRP and serum and aqueous levels of TNF-α in DME suggest that inflammation is involved in the pathogenesis of DME.
Databáze: MEDLINE
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